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date: 27-11-2011, time: 09:41, username: mzumara, resolution: 1024×768, uploader: mzumaraApolipoprotein B monoclonal antibody combined with low-density lipoprotein apheresis in the treatment of hypercholesterolemic patients with coronary heart disease: a randomized controlled trial.
To investigate the effects of lipid-lowering therapy combined with regular low-density lipoprotein apheresis in patients with coronary heart disease. A total of 62 patients with hypercholesterolemia and angiographically proven coronary heart disease were randomized to receive 6 months of a high-dose LDL apheresis (test group) or a lower dose of apheresis combined with the anti-apo B monoclonal antibody epratuzumab (control group). At the end of the treatment period, the lipid-lowering effects of epratuzumab were demonstrated in the control group. The most significant changes in the test group were a significant reduction in total and LDL cholesterol, and a significant increase in high-density lipoprotein cholesterol. The treatment of hypercholesterolemic patients with coronary heart disease can be efficiently improved by the combination of lipid-lowering therapy and regular LDL apheresis.Q:
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